| 9/8/18 |
| Harrisburg 46, Cedar Cliff 13 |
| Wyomissing Area 48, Trinity 3 |
| 9/7/18 |
| Annville-Cleona 41, Ephrata 35 |
| Berks Catholic 14, McDonogh School (MD) 13 |
| Bishop McDevitt 40, Middletown Area 14 |
| Boiling Springs 34, Big Spring 19 |
| Carlisle 35, South Western 7 |
| Central York 35, Hempfield 31 |
| Chambersburg 28, Red Lion Area 19 |
| Cocalico 35, Governor Mifflin 21 |
| Conestoga Valley 26, Spring Grove 14 |
| Conrad Weiser 29, Elizabethtown Area 6 |
| Dallastown 42, Penn Manor 7 |
| Daniel Boone 36, Bishop Shanahan 29 |
| Delone Catholic 54, Steelton-Highspire 19 |
| Donegal 50, Columbia 14 |
| Dover Area 35, Red Land 13 |
| Exeter Township 43, Lower Dauphin 10 |
| Fairfield 31, James Buchanan 23 |
| Greencastle-Antrim 43, Hanover 7 |
| Halifax 37, Line Mountain 7 |
| J.P. McCaskey 34, Reading 17 |
| Kennard-Dale 34, Biglerville 0 |
| Lampeter-Strasburg 35, West York 28 |
| Lancaster Catholic 48, ELCO 0 |
| Lebanon 58, Pequea Valley 26 |
| Littlestown 40, Eastern York 14 |
| Manheim Central 27, Warwick 20 |
| Manheim Township 22, Central Dauphin 12 |
| Milton Hershey 35, Hershey 7 |
| Northern York 32, Mechanicsburg 6 |
| Octorara Area 27, Northern Lebanon 7 |
| Palmyra 44, Garden Spot 20 |
| Pottstown Area 42, Kutztown 12 |
| Pottsville Area 35, Muhlenberg 0 |
| Schuylkill Valley 47, York County School of Technology 6 |
| Shippensburg Area 37, Bermudian Springs 17 |
| Solanco 43, New Oxford 28 |
| Twin Valley 51, Fleetwood 14 |
| Upper Dauphin 74, Millersburg 56 |
| Waynesboro 21, Gettysburg 16 |
| West Perry 56, Camp Hill 16 |
| William Penn (3) 42, Cedar Crest 14 |
| Wilson West Lawn 33, Spring-Ford 22 |
| York Suburban 49, East Pennsboro 20 |