| 10/20/18 |
| Harrisburg 64, Carlisle 10 |
| 10/19/18 |
| Annville-Cleona 31, ELCO 19 |
| Berks Catholic 57, Fleetwood 7 |
| Bermudian Springs 28, Littlestown 19 |
| Bishop McDevitt 49, Mechanicsburg 7 |
| Boiling Springs 56, Steelton-Highspire 55 |
| Cedar Cliff 30, Susquehanna Township 0 |
| Central Dauphin 35, Chambersburg 14 |
| Central York 35, Dallastown 28 |
| Cocalico 42, Solanco 7 |
| Columbia 34, Northern Lebanon 19 |
| Conrad Weiser 48, Muhlenberg 14 |
| Cumberland Valley 48, Central Dauphin East 17 |
| Daniel Boone 24, Twin Valley 21 |
| Ephrata 45, Pequea Valley 0 |
| Fairfield 47, York County School of Technology 16 |
| Gettysburg 28, Dover Area 7 |
| Governor Mifflin 34, Exeter Township 17 |
| Hamburg 56, Kutztown 0 |
| Hanover 28, Biglerville 27 |
| Hempfield 49, Penn Manor 14 |
| Juniata 55, Millersburg 7 |
| Lampeter-Strasburg 20, Elizabethtown Area 13 |
| Lancaster Catholic 22, Donegal 14 |
| Lebanon 28, Octorara Area 0 |
| Lower Dauphin 42, Hershey 25 |
| Manheim Central 63, Garden Spot 0 |
| Manheim Township 49, J.P. McCaskey 13 |
| Middletown Area 28, East Pennsboro 0 |
| Mifflin County 33, Greencastle-Antrim 14 |
| Milton Hershey 35, Camp Hill 14 |
| New Oxford 21, South Western 14 |
| Northern York 42, Big Spring 7 |
| Palmyra 14, Trinity 13 |
| Red Lion Area 46, Spring Grove 21 |
| Shippensburg Area 37, Red Land 0 |
| Susquehannock 28, Kennard-Dale 24 |
| Susquenita 20, Newport 16 |
| Warwick 35, Conestoga Valley 3 |
| Waynesboro 43, West Perry 40 |
| West York 22, York Suburban 19 |
| William Penn (3) 32, Northeastern 28 |
| Wilson West Lawn 42, Cedar Crest 21 |
| Wissahickon 58, Eastern York 43 |
| Wyomissing Area 49, Schuylkill Valley 13 |
| York Catholic 35, Delone Catholic 7 |