| 10/6/18 |
| Harrisburg 32, State College Area 17 |
| Schuylkill Valley 35, Fleetwood 7 |
| Wyomissing Area 47, Hamburg 0 |
| 10/5/18 |
| Annville-Cleona 54, Pequea Valley 18 |
| Berks Catholic 63, Kutztown 0 |
| Big Spring 26, Greencastle-Antrim 22 |
| Biglerville 28, York County School of Technology 0 |
| Bishop McDevitt 56, Lower Dauphin 7 |
| Cedar Cliff 48, Hershey 7 |
| Cedar Crest 45, Penn Manor 7 |
| Central York 58, Spring Grove 14 |
| Chambersburg 26, Central Dauphin East 20 |
| Cocalico 49, Conestoga Valley 14 |
| Cumberland Valley 35, Carlisle 14 |
| Dallastown 45, New Oxford 14 |
| Delone Catholic 17, Bermudian Springs 7 |
| Dover Area 34, York Suburban 12 |
| East Pennsboro 48, Trinity 6 |
| ELCO 39, Donegal 33 |
| Elizabethtown Area 65, Garden Spot 28 |
| Ephrata 28, Columbia 26 |
| Exeter Township 51, Reading 14 |
| Gettysburg 45, Kennard-Dale 7 |
| Governor Mifflin 49, Daniel Boone 0 |
| Halifax 31, Susquenita 6 |
| Lancaster Catholic 43, Octorara Area 0 |
| Lebanon 56, Northern Lebanon 18 |
| Littlestown 42, Hanover 3 |
| Manheim Central 43, Lampeter-Strasburg 7 |
| Manheim Township 28, Warwick 20 |
| Mechanicsburg 21, Red Land 0 |
| Newport 20, Line Mountain 13 |
| Northeastern 38, South Western 16 |
| Northern York 41, Susquehannock 14 |
| Palmyra 47, Boiling Springs 7 |
| Red Lion Area 21, William Penn (3) 20 |
| Shippensburg Area 34, West Perry 21 |
| Solanco 64, J.P. McCaskey 10 |
| Steelton-Highspire 55, Camp Hill 21 |
| Susquehanna Township 19, Conrad Weiser 6 |
| Twin Valley 38, Muhlenberg 17 |
| Upper Dauphin 21, Juniata 0 |
| West York 34, Eastern York 33 |
| Wilson West Lawn 26, Hempfield 16 |
| York Catholic 41, Fairfield 10 |
| 10/4/18 |
| Middletown Area 32, Milton Hershey 21 |